Allergic Reactions to Anaesthetic Agents

It should be noted that serum tryptase estimations are now being performed by both the Alfred and Royal Melbourne Hospitals. The test measures total tryptase (that is, alpha pro tryptase and beta tryptase).

A potential problem is that a rise in beta tryptase (associated with anaphylaxis) may be masked if the total tryptase falls within normal levels. There is therefore, a fairly high false negative rate for intra-operative anaphylaxis and a normal total tryptase does not completely exclude anaphylaxis: thus referral for skin testing is still indicated.

The Royal Melbourne Hospital Anaesthetic Department, in conjunction with the Allergy and Clinical Immunology Department has developed a full referral and follow up skin testing service. Patients requiring referral must have complete documentation and the necessary forms can be downloaded from this website. Dr Garry Donnan is the Anaesthetic Specialist involved and his contact details are provided on the form.

Suspected Anaphylaxis During Anaesthesia Report Form (114kb, MS Word)