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Iron deficiency

Page content: Iron deficiency | Why is iron important? | Why does iron deficiency occur? | Dietary sources of iron | Consequences of iron deficiency | Practical strategies to increase dietary iron | References | Download document

Iron deficiency

Iron deficiency is the most common nutritional deficiency worldwide. Depletion of iron stores and iron deficiency occur in all age groups, but particularly in infants, young children, the elderly and women of childbearing age. Low iron stores have been reported in up to 1/3 of young children aged 1-3 years in Australia. A study of Arabic-speaking families in Sydney demonstrated a prevalence of impaired iron status in 38% of 1-3 year-olds.

Why is iron important?

Iron is stored in red blood cells as part of haemoglobin, and assists in the transport of oxygen around the body. Iron is vital for brain development.

Why does iron deficiency occur?

In term babies, iron stores are adequate until around 6 months, after which a dietary source of iron is required.

In the premature infant, not only is total body iron lower than the full-term infant, but also these infants have a faster rate of post-natal growth and become iron-depleted more quickly than full-term babies.

The young toddler’s diet is most at risk of iron deficiency, due in part to the proportionately high requirements in the second half of the first year, combined with some children’s preference for lower iron containing foods.

Risk factors for the development of iron deficiency in children include:
prematurity, low birth weight, gastrointestinal disease (malabsorption or blood loss), exclusive breastfeeding beyond 6 months, introduction of cow’s milk as the main drink before 12 months, and high intake of cow’s milk, delayed introduction of solids, low (or no) meat intake and general poor diet in the second year.

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Dietary sources of iron

Recommended dietary intakes of iron
The current Australian recommended dietary intakes of iron range from 0.5mg/day for breastfed infants to 3 mg/day for formula-fed infants, 9mg/day for 7-12month olds, 6-8 mg/day for 1-11 year olds, and 10-13 mg/day for 12-18 year olds.

Breastfed infants
Exclusively breastfed infants receive an adequate iron intake for around 6 months, and iron deficiency is uncommon in full-term breastfed infants, due to the highly efficient absorption of iron from breast milk. Changes to the maternal diet or maternal supplements of iron do not affect the iron composition of breast milk and confer no advantage to the infant. Mothers on iron supplements for their own benefit, should of course continue these supplements as advised.

Formula-fed infants
All infant formulas contain between 7 and 12 mg iron per 1000mls, therefore providing adequate dietary iron for infants in a volume of formula around 700-1000mls per day.

Foods
The best sources of dietary iron for young children are red meats such as lamb and beef, with moderate amounts in fish and chicken. These foods contain ‘haem’ iron with a bioavailability, or absorption factor, of around 10%. Non-haem sources of iron have a lower bioavailability and are found in fortified breakfast cereals, eggs, legumes, wholegrain bread and cereals, and some vegetables.

The addition of foods rich in Vitamin C, such as citrus fruit, tomatoes or berries to a meal can greatly increase the absorption of iron from that meal in a dose-dependent way.

Consequences of iron deficiency

Iron intakes of young children in Australia seem to be low: in the 1995 National Nutrition Survey around one-third of 2-3 year-olds had iron intakes below the recommended dietary intake on the day of the survey, and ten percent were below 70% of the RDI.

Symptoms of iron deficiency such as lethargy and poor development may occur before the blood levels of haemoglobin decrease. Iron deficiency has been linked with developmental problems such as psychomotor and mental delay and reduced immune function. Some studies suggest that treatment to correct the iron deficiency does not necessarily allow full ‘catch up’ to expected developmental levels. A large number of iron deficient children will have no symptoms at all and are undiagnosed until the child has a medical examination for an unrelated reason.

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Practical strategies to increase dietary iron

Include red meat 3 to 4 times per week. It is recommended that young children consume between a half and one serving of meat or meat alternatives per day. A sample serve is 65-100 g cooked meat or chicken, half a cup of cooked dried beans, lentils, chick peas or canned beans, 80-120g of cooked fish fillet, 2 small eggs, one-third of a cup of nuts (or nut paste).

Include a food rich in Vitamin C, such as tomato, capsicum, berries, orange or mandarin with non-meat sources of iron.

Toddlers who are reluctant eaters may be encouraged to consume adequate iron with foods such as minced meats, fortified breakfast cereals, smooth nut pastes and eggs.

Limit cow’s milk to 600 mls per day.

In some cases a child multivitamin and mineral may be recommended to supplement a poor dietary iron intake, whilst longer-term feeding strategies can be introduced.

References

  • Australian Bureau of Statistics. National Nutrition Survey, Australia 1995. ABS Canberra, Australian Bureau of Statistics, 1999
  • Ballot D, Baynes RD, Bothwell TH et al. The effects of fruit juices and fruits on the absorption of iron from a rice meal. Brit J Nutr 1987;57:331-343
  • Children’s Health Development Foundation and Deakin University. The Australian Guide to Healthy Eating. Canberra: AGPS, 1995
  • Karr MA, Mira M, Alperstein G, Labib S, Webster BH. Iron deficiency in Australian-born children of Arabic background in central Sydney. Med J Aust 2001;174:165-168
  • Lozoff B, Brittenham GM, Wolf AW et al. Iron deficiency anaemia and iron therapy effects on infant development test performance. Pediatrics 1987;79:981-995
  • Lozoff B, Joimenez E, Wolf AW. Long term developmental outcome of infants with iron deficiency. New Engl J Med. 1991;325(10):687-94
  • Mira M, Alperstein G, Karr M, Ranmuthugala G, Causer J et al. Haem iron intake in 12-36-month-old children depleted in iron: case-control study. BMJ 1996;312:881-883
  • National Health & Medical Research Council. Recommended dietary intakes for use in Australia. Canberra, AGPS, 1991
  • National Health & Medical Research Council. Dietary Guidelines for Children and Adolescents, 2003
  • Oski FA Honig AS. The effects of therapy on the developmental scores of iron deficient infants. J Pediatr 1978;92:21-25
  • Oti-Boateng P, Seshadri R, Petrick S, Gibson RA, Simmer K. Iron status and dietary iron intake of 6-24 month-old children in Adelaide. J Paediatr Child Health 1998;34(3):250-253
  • Sherman AR. Zinc, copper and iron nutrition and immunity. J Nutr 1992;122:604-9

Prepared by the Department of Nutrition and Food Services Royal Children's Hospital

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Last updated: 13 March, 2008
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